CP-154,526

CP-154,526

chembox new
ImageFile = CP154526.svg
ImageSize = 200px
IUPACName = N-butyl-N-ethyl-2,5-dimethyl-7-(2,4,6-trimethylphenyl)pyrrolo [3,2-e] pyrimidin-4-amine
OtherNames =
Section1 = Chembox Identifiers
CASNo=157286-86-7
PubChem=5311055
SMILES=CCCCN(CC)C1=NC(=NC2=C1C(=CN2C3=C(C=C(C=C3C)C)C)C)C

Section2 = Chembox Properties
Formula=C23H32N4
MolarMass=364.52698
Appearance=
Density=
MeltingPt=
BoilingPt=
Solubility=

Section3 = Chembox Hazards
MainHazards=
FlashPt=
Autoignition=

CP-154,526 is a potent and selective antagonist of the corticotropin releasing hormone receptor 1 developed by Pfizer.cite journal | author = Schulz DW, Mansbach RS, Sprouse J, Braselton JP, Collins J, Corman M, Dunaiskis A, Faraci S, Schmidt AW, Seeger T, Seymour P, Tingley FD 3rd, Winston EN, Chen YL, Heym J | title = CP-154,526: a potent and selective nonpeptide antagonist of corticotropin releasing factor receptors | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 93 | issue = 19 | pages = 10477–82 | year = 1996 | month = September | pmid = 8816826 | pmc = 38410 | url = http://www.pnas.org/content/93/19/10477.abstract | issn = ]

CP-154,526 is under investigation for the potential treatment of alcoholism.cite web | url = http://www.sciencedaily.com/releases/2008/07/080730175518.htm | title = Drug Has Potential To Prevent Alcoholics From Relapsing | author = | authorlink = | coauthors = | date = 2008-08-02 | format = | work = Science News | publisher = ScienceDaily | pages = | language = | archiveurl = | archivedate = | quote = | accessdate = 2008-08-09] cite journal | author = Pastor R, McKinnon CS, Scibelli AC, Burkhart-Kasch S, Reed C, Ryabinin AE, Coste SC, Stenzel-Poore MP, Phillips TJ | title = Corticotropin-releasing factor-1 receptor involvement in behavioral neuroadaptation to ethanol: a urocortin1-independent mechanism | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 105 | issue = 26 | pages = 9070–5 | year = 2008 | month = July | pmid = 18591672 | doi = 10.1073/pnas.0710181105 | url = | issn = ]

ee also

* Antalarmin
* Pexacerfont
* Corticotropin releasing hormone antagonist

References

External links

*


Wikimedia Foundation. 2010.

Игры ⚽ Поможем сделать НИР

Look at other dictionaries:

  • No. 526 Squadron RAF — Active 15 June 1943 1 May 1945 Country United Kingdom …   Wikipedia

  • Д-30КУ-154 — Д 30КУ …   Википедия

  • U-526 — История корабля Государство флага …   Википедия

  • U-154 (1941) — У этого термина существуют и другие значения, см. U 154. U 154 История корабля Государство флага …   Википедия

  • No. 154 Squadron RAF — No. 154 (Motor Industries) Squadron RAF Active 7 August 1918 – 11 September 1918 15 June 1941 – 1 Nov 1944 16 Nov 1944 – 31 March 1945 Country …   Wikipedia

  • ВАЗ-526 — Производитель: АвтоВАЗ Тип: роторно поршневой двигатель Технические характеристики Объём: 4 x 0,654 Мощность: 400 л.с Система охлаждения: жидкостное охлаждение Размеры Длина: 1386 мм …   Википедия

  • КЛАССОВАЯ БОРЬБА — столкновение и противодействие интересов классов. О несовпадении интересов различных социальных групп друг с другом, об их конфликтах между собой издавна писали историки и философы. Аристотель, Т. Гоббс, Г.В.Ф. Гегель и др. рассматривали конфликт …   Философская энциклопедия

  • Ostrogoths —    A barbarian people whose name means Goths of the rising sun, or Goths glorified by the rising sun, or simply East Goths, the Ostrogoths played an important role in the history of the later Roman Empire. Identified as early as the first century …   Encyclopedia of Barbarian Europe

  • Afamelanotide — Other names Melanotan Melanotan 1 Melanotan 1 Melanotan I Melanotan I [Nle4, D Phe …   Wikipedia

  • Corticotropin-releasing hormone — PDB rendering based on 1go9 …   Wikipedia

Share the article and excerpts

Direct link
Do a right-click on the link above
and select “Copy Link”