Cilastatin

Cilastatin
Cilastatin
Systematic (IUPAC) name
(Z)-7-[(2R)-2-amino-3-hydroxy-3-oxopropyl]sulfanyl-2-{[(1S)-
2,2-dimethylcyclopropanecarbonyl]amino}hept-2-enoic acid
Clinical data
AHFS/Drugs.com International Drug Names
MedlinePlus a686013
Pregnancy cat.  ?
Legal status  ?
Identifiers
CAS number 82009-34-5 YesY
ATC code  ?
PubChem CID 5280454
DrugBank EXPT00918
ChemSpider 4940183 YesY
UNII 141A6AMN38 YesY
KEGG D07698 YesY
ChEBI CHEBI:3697 YesY
ChEMBL CHEMBL766 YesY
Chemical data
Formula C16H26N2O5S 
Mol. mass 358.454 g/mol
SMILES eMolecules & PubChem
 N(what is this?)  (verify)

Cilastatin is a chemical compound which inhibits the human enzyme dehydropeptidase.[1]

Dehydropeptidase is found in the kidney and is responsible for degrading the antibiotic imipenem. Cilastatin is therefore combined intravenously with imipenem in order to protect it from dehydropeptidase and prolong its antibacterial effect. However, cilastatin itself does not have antibiotic activity.

Another carbapenem, meropenem is resistant to dehydropeptidase; therefore, it can be given without cilastatin.

References

See also


Wikimedia Foundation. 2010.

Игры ⚽ Нужна курсовая?

Look at other dictionaries:

  • Cilastatin — Strukturformel Allgemeines Freiname Cilastatin …   Deutsch Wikipedia

  • cilastatin sodium — An inhibitor of the renal dipeptidase, dehydropeptidase 1, used, in conjunction with antibiotics subject to metabolism in the kidneys, to increase therapeutic response to the antibiotic. * * * cil·a·sta·tin so·di·um (si″lə statґin) a… …   Medical dictionary

  • cilastatin — noun A dehydropeptidase inhibitor that is used in association with certain antibiotics to prevent them being inactivated …   Wiktionary

  • Imipenem/cilastatin — Combination of Imipenem Carbapenem antibiotic Cilastatin Dehydropeptidase inhibitor Clinical data MedlinePlus …   Wikipedia

  • Imipenem — Systematic (IUPAC) name (5R,6S) 6 [(1R) 1 hydroxyethyl] 3 ({2 [(iminomethyl)amino]ethyl}thio) 7 oxo 1 azabicyclo[3.2.0]hept 2 ene 2 carboxylic acid Clinical data …   Wikipedia

  • Dietmar Wittmann — Dietmar H. Wittmann, M.D., Ph.D., FACS is an academic surgeon specializing in complex abdominal surgery. He was associated with the following medical schools: University of Hamburg, Germany, University of Düsseldorf, Germany, University of… …   Wikipedia

  • Carbapenem — Carbapenems are a class of beta lactam antibiotics with a broad spectrum of antibacterial activity, and have a structure which renders them highly resistant to beta lactamases. Carbapenem antibiotics were originally developed from thienamycin, a… …   Wikipedia

  • Imipenem — Strukturformel Allgemeines Freiname Imipenem Andere Namen …   Deutsch Wikipedia

  • Merck & Co. — Merck Co., Inc. (Merck Sharp Dohme (MSD) outside the United States and Canada) Type Public Traded as NYSE:  …   Wikipedia

  • Meropenem — Systematic (IUPAC) name 3 [5 (dimethylc …   Wikipedia

Share the article and excerpts

Direct link
Do a right-click on the link above
and select “Copy Link”