Topotecan

Topotecan

drugbox
IUPAC_name = ("S")-10- [(dimethylamino)methyl] -4-ethyl-4,9-
dihydroxy-1"H"-pyrano [3',4':6,7] indolizino [1,2-b]
quinoline-3,14(4"H",12"H")-dione monohydrochloride



CAS_number = 123948-87-8
CAS_supplemental = 119413-54-6 (hydrochloride)
ATC_prefix = L01
ATC_suffix = XX17
PubChem = 6419854
DrugBank = APRD00687
C = 23 |H = 23 |N = 3 |O = 5 •HCl
molecular_weight = 457.9 g/mol
bioavailability = NA
protein_bound = 35%
metabolism = Hepatic
elimination_half-life = 2-3 hours
excretion = Renal
pregnancy_category = D (Au, U.S.)
legal_status = ℞-only (U.S.), POM (UK)
routes_of_administration = Intravenous infusion, oral

Topotecan hydrochloride (trade name Hycamtin) is a chemotherapy agent that is a topoisomerase 1 inhibitor. It is used to treat ovarian cancer and lung cancer, as well as other cancer types.

After GlaxoSmithKline received final FDA approval for Hycamtin Capsules on October 15, 2007, Topotecan is the first topoisomerase inhibitor for oral use.

Administration

IV, oral.

ide effects

*Diarrhea
*Low blood counts
*Susceptibility to infection

External links

* [http://www.cancer.gov/Templates/drugdictionary.aspx?CdrID=41185 NCI Drug Dictionary Definition of Topotecan]
* [http://www.cancer.gov/cancertopics/druginfo/topotecanhydrochloride NCI Drug Information for Patients]


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Look at other dictionaries:

  • Topotécan — Général Nom IUPAC (S) 10 [(diméthylamino)méthyl] 4 éthyl 4,9 dihydroxy 1H pyrano[3 ,4 :6,7]indolizino[1,2 b]quinoline 3,14(4H,12H) dione …   Wikipédia en Français

  • Topotecán — Identificadores Número CAS …   Wikipedia Español

  • Topotecan — Strukturformel Allgemeines Freiname Topotecan Andere Namen …   Deutsch Wikipedia

  • topotecan — A drug used to treat certain types of ovarian cancer, lung cancer, and cervical cancer. Topotecan is a type of topoisomerase inhibitor. Also called topotecan hydrochloride and Hycamtin …   English dictionary of cancer terms

  • topotecan hydrochloride — A drug used to treat certain types of ovarian cancer, lung cancer, and cervical cancer. Topotecan hydrochloride is a type of topoisomerase inhibitor. Also called topotecan and Hycamtin …   English dictionary of cancer terms

  • topotecan — noun A particular drug used in chemotherapy. Syn: hydrochloride, HCl …   Wiktionary

  • topotecan — A topoisomerase I inhibitor with antitumor activity used in the treatment of ovarian cancer. * * * n. see topoisomerase inhibitor …   Medical dictionary

  • topotecan — n.; see topoisomerase inhibitor …   The new mediacal dictionary

  • topotecan hydrochloride — to·po·te·can hy·dro·chlo·ride (to″po teґkan) a cytotoxic topoisomerase inhibitor derived from camptothecin, acting by preventing the rejoining of DNA strands following breakage by DNA topoisomerase; this leads to double strand DNA breakage… …   Medical dictionary

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