Dequalinium

Dequalinium chloride
IUPAC name 1,1'-decane-1,10-diylbis(4-amino-2-methylquinolinium) decyl]-2-methyl-4-quinolin-1-iumamine dichloride
Identifiers
PubChem	10649
ChemSpider	2886 Y
UNII	E7QC7V26B8 Y
DrugBank	DB04209
MeSH	Dequalinium
ChEMBL	CHEMBL333826 N, CHEMBL121663
Jmol-3D images	Image 1
SMILES c12ccccc1c(cc([n+]2CCCCCCCCCC[n+]4c3ccccc3c(N)cc4C)C)N
InChI InChI=1S/C30H38N4/c1-23-21-27(31)25-15-9-11-17-29(25)33(23)19-13-7-5-3-4-6-8-14-20-34-24(2)22-28(32)26-16-10-12-18-30(26)34/h9-12,15-18,21-22,31-32H,3-8,13-14,19-20H2,1-2H3/p+2 Y Key: PCSWXVJAIHCTMO-UHFFFAOYSA-P Y InChI=1/C30H38N4/c1-23-21-27(31)25-15-9-11-17-29(25)33(23)19-13-7-5-3-4-6-8-14-20-34-24(2)22-28(32)26-16-10-12-18-30(26)34/h9-12,15-18,21-22,31-32H,3-8,13-14,19-20H2,1-2H3/p+2 Key: PCSWXVJAIHCTMO-SKRXCDHZAO
Properties
Molecular formula	C30H40Cl2N4
Molar mass	527.57 g mol−1
N (verify) (what is: Y/N?) Except where noted otherwise, data are given for materials in their standard state (at 25 °C, 100 kPa)
Infobox references

Dequalinium is a quaternary ammonium cation commonly available as the dichloride salt. The bromide, iodide, acetate, and undecenoate salts are known as well. Dequalinium chloride is the active ingredient of several medications:

Dequadin an antiseptic and disinfectant. It is a topical bacteriostat. It is used in wound dressings and mouth infections and may also have antifungal action. It may cause skin ulceration.

Fluomizin, vaginal tablets containing 10 mg dequalinium chloride, are used for treating vaginal bacterial conditions (i.e. Bacterial Vaginosis).

The dequalinium dication is symmetrical, containing two quaternary quinolinium units linked by a dodecylene chain.

Applications

Dequalinium salts may be used to treat malaria.^[1] As dequalinium chloride, it can be used in lozenges to cure sore throats however while this is effective in vitro, it is not effective in cases of streptococci infections ^[2]

References

1. ^ "US Patent 4946849". United States Patents and Trademarks Office (USPTO). 10 October 1989. http://patft.uspto.gov/netacgi/nph-Parser?Sect1=PTO1&Sect2=HITOFF&d=PALL&p=1&u=%2Fnetahtml%2FPTO%2Fsrchnum.htm&r=1&f=G&l=50&s1=4946849.PN.&OS=PN/4946849&RS=PN/4946849. Retrieved 2008-03-15. 
2. ^ Krämer W. (1977). "[Treatment of tonsilitis with dequalinium choride]" (in German). Fortschr Med. 95 (16): 1108–10. PMID 856702. 

Further reading

• Gamboa-Vujicic, Gisela; Emma, Dennis A.; Liao, Shu Y.; Fuchtner, Carlos; Manetta, Alberto (1993). "Toxicity of the mitochondrial poison dequalinium chloride in a murine model system". Journal of Pharmaceutical Sciences 82 (3): 231. doi:10.1002/jps.2600820302. PMID 8450414. 

External links

• International Mark - Fluomizin(804560)
• Medinova Fluomizin
• Comparative Study of Efficacy of 10 mg Dequalinium Chloride (Fluomizin) in the Local Treatment of Bacterial Vaginosis

This drug article relating to the genito-urinary system is a stub. You can help Wikipedia by expanding it.v · Categories: Quinolines Quaternary ammonium compounds Antiseptics Genito-urinary system drug stubs Wikimedia Foundation. 2010. Игры ⚽ Нужна курсовая? Now That's What I Call Exactshit DVD 2 Adam Bohorič Look at other dictionaries: dequalinium chloride — Dequalinium acetate, with chloride replacing acetate, used as an antimicrobial agent primarily in lozenges for the treatment of mouth and throat infections …   Medical dictionary dequalinium — n. an antiseptic, active against some bacteria and fungi, used as lozenges to treat mouth and throat infections. Trade names: Dequadin, Labosept …   Medical dictionary dequalinium acetate — An antimicrobial agent. SYN: decamine …   Medical dictionary Деквалиниум (Dequalinium) — антисептик, активный против ряда бактерий и грибков; применяется в виде леденцов для лечения инфекционных заболеваний полости рта и глотки. Торговое название: лабосепт (Labosept). Источник: Медицинский словарь …   Медицинские термины ДЕКВАЛИНИУМ — (dequalinium) антисептик, активный против ряда бактерий и грибков; применяется в виде леденцов для лечения инфекционных заболеваний полости рта и глотки. Торговое название: лабосепт (Labosept) …   Толковый словарь по медицине DSDMAC — Als kationische Tenside bezeichnet man Tenside, die eine positiv geladene funktionelle Gruppe besitzen. Wie jedes Tensid sind auch die kationischen Tenside aus einem polaren und einem unpolaren Teil aufgebaut. Als unpolarer Teil dienen… …   Deutsch Wikipedia Esterquat — Als kationische Tenside bezeichnet man Tenside, die eine positiv geladene funktionelle Gruppe besitzen. Wie jedes Tensid sind auch die kationischen Tenside aus einem polaren und einem unpolaren Teil aufgebaut. Als unpolarer Teil dienen… …   Deutsch Wikipedia Esterquats — Als kationische Tenside bezeichnet man Tenside, die eine positiv geladene funktionelle Gruppe besitzen. Wie jedes Tensid sind auch die kationischen Tenside aus einem polaren und einem unpolaren Teil aufgebaut. Als unpolarer Teil dienen… …   Deutsch Wikipedia Invertseife — Als kationische Tenside bezeichnet man Tenside, die eine positiv geladene funktionelle Gruppe besitzen. Wie jedes Tensid sind auch die kationischen Tenside aus einem polaren und einem unpolaren Teil aufgebaut. Als unpolarer Teil dienen… …   Deutsch Wikipedia Phenol — This article is about the molecule. For the class of chemicals containing a phenol group, see Phenols. Phenol …   Wikipedia 18+ © Academic, 2000-2024 Contact us: Technical Support, Advertising Dictionaries export, created on PHP, Joomla, Drupal, WordPress, MODx. Mark and share Search through all dictionaries Translate… Search Internet Share the article and excerpts Direct link … Do a right-click on the link above and select “Copy Link”