P2RX7

P2RX7
Purinergic receptor P2X, ligand-gated ion channel, 7
Identifiers
Symbols P2RX7; MGC20089; P2X7
External IDs OMIM602566 MGI1339957 HomoloGene1925 GeneCards: P2RX7 Gene
RNA expression pattern
PBB GE P2RX7 207091 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 5027 18439
Ensembl ENSG00000089041 ENSMUSG00000029468
UniProt Q99572 Q3UN00
RefSeq (mRNA) NM_002562.5 NM_001038839
RefSeq (protein) NP_002553.3 NP_001033928
Location (UCSC) Chr 12:
121.57 – 121.62 Mb
Chr 5:
123.09 – 123.14 Mb
PubMed search [1] [2]

P2X purinoceptor 7 is a protein that in humans is encoded by the P2RX7 gene.[1][2]

The product of this gene belongs to the family of purinoceptors for ATP. This receptor functions as a ligand-gated ion channel and is responsible for ATP-dependent lysis of macrophages through the formation of membrane pores permeable to large molecules. Multiple alternatively spliced variants which would encode different isoforms have been identified although some fit nonsense-mediated decay (NMD) criteria.[3]

In melanocytic cells P2RX7 gene expression may be regulated by MITF[4].

Contents

Recruitment of pannexin

Activation of the P2RX7 receptor by ATP leads to recruitment of pannexin pores[5] which allow small molecules such as ATP to leak out of cells. This allows further activation of purinergic receptors and physiological responses such a spreading cytoplasmic waves of calcium[6]

See also

References

  1. ^ Rassendren F, Buell GN, Virginio C, Collo G, North RA, Surprenant A (Apr 1997). "The permeabilizing ATP receptor, P2X7. Cloning and expression of a human cDNA". J Biol Chem 272 (9): 5482–6. doi:10.1074/jbc.272.9.5482. PMID 9038151. 
  2. ^ Buell GN, Talabot F, Gos A, Lorenz J, Lai E, Morris MA, Antonarakis SE (Feb 1999). "Gene structure and chromosomal localization of the human P2X7 receptor". Receptors Channels 5 (6): 347–54. PMID 9826911. 
  3. ^ "Entrez Gene: P2RX7 purinergic receptor P2X, ligand-gated ion channel, 7". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5027. 
  4. ^ Hoek KS, Schlegel NC, Eichhoff OM et al. (2008). "Novel MITF targets identified using a two-step DNA microarray strategy". Pigment Cell Melanoma Res. 21 (6): 665–76. doi:10.1111/j.1755-148X.2008.00505.x. PMID 19067971. 
  5. ^ Iglesias, R.; Locovei, S.; Roque, A.; Alberto, A. P.; Dahl, G.; Spray, D. C.; Scemes, E. (2008). "P2X7 receptor-Pannexin1 complex: Pharmacology and signaling". AJP: Cell Physiology 295 (3): C752–C760. doi:10.1152/ajpcell.00228.2008. PMC 2544446. PMID 18596211. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2544446.  edit
  6. ^ Boison, D.; Chen, J. -F.; Fredholm, B. B. (2009). "Adenosine signaling and function in glial cells". Cell Death and Differentiation 17 (7): 1071–1082. doi:10.1038/cdd.2009.131. PMC 2885470. PMID 19763139. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2885470.  edit

Further reading

External links

Ionotropic glutamates ATP-gated channels B trdu: iter (nrpl/grfl/cytl/horl), csrc (lgic, enzr, gprc, igsr, intg, nrpr/grfr/cytr), itra (adap, gbpr, mapk), calc, lipd; path (hedp, wntp, tgfp+mapp, notp, jakp, fsap, hipp, tlrp)

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