MRE11A

MRE11A
MRE11 meiotic recombination 11 homolog A (S. cerevisiae)
Identifiers
Symbols MRE11A; ATLD; HNGS1; MRE11; MRE11B
External IDs OMIM600814 MGI1100512 HomoloGene4083 GeneCards: MRE11A Gene
RNA expression pattern
PBB GE MRE11A 205395 s at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 4361 17535
Ensembl ENSG00000020922 ENSMUSG00000031928
UniProt P49959 Q3TU24
RefSeq (mRNA) NM_005590.3 NM_018736.2
RefSeq (protein) NP_005581.2 NP_061206.1
Location (UCSC) Chr 11:
94.15 – 94.23 Mb
Chr 9:
14.59 – 14.64 Mb
PubMed search [1] [2]

Double-strand break repair protein MRE11A is a protein that in humans is encoded by the MRE11A gene.[1]

This gene encodes a nuclear protein involved in homologous recombination, telomere length maintenance, and DNA double-strand break repair. By itself, the protein has 3' to 5' exonuclease activity and endonuclease activity. The protein forms a complex with the RAD50 homolog; this complex is required for nonhomologous joining of DNA ends and possesses increased single-stranded DNA endonuclease and 3' to 5' exonuclease activities. In conjunction with a DNA ligase, this protein promotes the joining of noncomplementary ends in vitro using short homologies near the ends of the DNA fragments. This gene has a pseudogene on chromosome 3. Alternative splicing of this gene results in two transcript variants encoding different isoforms.[2]

Interactions

MRE11A has been shown to interact with Ku70,[3] Ataxia telangiectasia mutated,[4][5] MDC1,[6] Rad50,[3][5][7][8][9] Nibrin,[5][9][10][11][12] TERF2[13] and BRCA1.[5][7][14][15]

References

  1. ^ Petrini JH, Walsh ME, DiMare C, Chen XN, Korenberg JR, Weaver DT (Feb 1996). "Isolation and characterization of the human MRE11 homologue". Genomics 29 (1): 80–6. doi:10.1006/geno.1995.1217. PMID 8530104. 
  2. ^ "Entrez Gene: MRE11A MRE11 meiotic recombination 11 homolog A (S. cerevisiae)". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4361. 
  3. ^ a b Goedecke, W; Eijpe M, Offenberg H H, van Aalderen M, Heyting C (Oct. 1999). "Mre11 and Ku70 interact in somatic cells, but are differentially expressed in early meiosis". Nat. Genet. (UNITED STATES) 23 (2): 194–8. doi:10.1038/13821. ISSN 1061-4036. PMID 10508516. 
  4. ^ Kim, S T; Lim D S, Canman C E, Kastan M B (Dec. 1999). "Substrate specificities and identification of putative substrates of ATM kinase family members". J. Biol. Chem. (UNITED STATES) 274 (53): 37538–43. doi:10.1074/jbc.274.53.37538. ISSN 0021-9258. PMID 10608806. 
  5. ^ a b c d Wang, Y; Cortez D, Yazdi P, Neff N, Elledge S J, Qin J (Apr. 2000). "BASC, a super complex of BRCA1-associated proteins involved in the recognition and repair of aberrant DNA structures". Genes Dev. (UNITED STATES) 14 (8): 927–39. ISSN 0890-9369. PMC 316544. PMID 10783165. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=316544. 
  6. ^ Xu, Xingzhi; Stern David F (Oct. 2003). "NFBD1/MDC1 regulates ionizing radiation-induced focus formation by DNA checkpoint signaling and repair factors". FASEB J. (United States) 17 (13): 1842–8. doi:10.1096/fj.03-0310com. PMID 14519663. 
  7. ^ a b Chiba, N; Parvin J D (Oct. 2001). "Redistribution of BRCA1 among four different protein complexes following replication blockage". J. Biol. Chem. (United States) 276 (42): 38549–54. doi:10.1074/jbc.M105227200. ISSN 0021-9258. PMID 11504724. 
  8. ^ Dolganov, G M; Maser R S, Novikov A, Tosto L, Chong S, Bressan D A, Petrini J H (Sep. 1996). "Human Rad50 is physically associated with human Mre11: identification of a conserved multiprotein complex implicated in recombinational DNA repair". Mol. Cell. Biol. (UNITED STATES) 16 (9): 4832–41. ISSN 0270-7306. PMC 231485. PMID 8756642. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=231485. 
  9. ^ a b Trujillo, K M; Yuan S S, Lee E Y, Sung P (Aug. 1998). "Nuclease activities in a complex of human recombination and DNA repair factors Rad50, Mre11, and p95". J. Biol. Chem. (UNITED STATES) 273 (34): 21447–50. doi:10.1074/jbc.273.34.21447. ISSN 0021-9258. PMID 9705271. 
  10. ^ Cerosaletti, Karen M; Concannon Patrick (Jun. 2003). "Nibrin forkhead-associated domain and breast cancer C-terminal domain are both required for nuclear focus formation and phosphorylation". J. Biol. Chem. (United States) 278 (24): 21944–51. doi:10.1074/jbc.M211689200. ISSN 0021-9258. PMID 12679336. 
  11. ^ Matsuzaki, Kenichiro; Shinohara Akira, Shinohara Miki (May. 2008). "Forkhead-associated domain of yeast Xrs2, a homolog of human Nbs1, promotes nonhomologous end joining through interaction with a ligase IV partner protein, Lif1". Genetics (United States) 179 (1): 213–25. doi:10.1534/genetics.107.079236. ISSN 0016-6731. PMC 2390601. PMID 18458108. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2390601. 
  12. ^ Desai-Mehta, A; Cerosaletti K M, Concannon P (Mar. 2001). "Distinct functional domains of nibrin mediate Mre11 binding, focus formation, and nuclear localization". Mol. Cell. Biol. (United States) 21 (6): 2184–91. doi:10.1128/MCB.21.6.2184-2191.2001. ISSN 0270-7306. PMC 86852. PMID 11238951. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=86852. 
  13. ^ Zhu, X D; Küster B, Mann M, Petrini J H, de Lange T (Jul. 2000). "Cell-cycle-regulated association of RAD50/MRE11/NBS1 with TRF2 and human telomeres". Nat. Genet. (UNITED STATES) 25 (3): 347–52. doi:10.1038/77139. ISSN 1061-4036. PMID 10888888. 
  14. ^ Paull, T T; Cortez D, Bowers B, Elledge S J, Gellert M (May. 2001). "Direct DNA binding by Brca1". Proc. Natl. Acad. Sci. U.S.A. (United States) 98 (11): 6086–91. doi:10.1073/pnas.111125998. ISSN 0027-8424. PMC 33426. PMID 11353843. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=33426. 
  15. ^ Zhong, Q; Chen C F, Li S, Chen Y, Wang C C, Xiao J, Chen P L, Sharp Z D, Lee W H (Jul. 1999). "Association of BRCA1 with the hRad50-hMre11-p95 complex and the DNA damage response". Science (UNITED STATES) 285 (5428): 747–50. doi:10.1126/science.285.5428.747. ISSN 0036-8075. PMID 10426999. 

Further reading




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Look at other dictionaries:

  • MRE11A — MRE11 meiotic recombination 11 homolog A (S. cerevisiae) HUGO 7230 Símbolo MRE11A Símbolos alt. ATLD; HNGS1; MRE11; …   Wikipedia Español

  • Nibrin — Identifiers Symbols NBN; AT V1; AT V2; ATV; FLJ10155; MGC87362; NBS; NBS1; P95 External IDs …   Wikipedia

  • Ku70 — Estructura tridimensional de la proteína Ku70. HUGO 4055 …   Wikipedia Español

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