Physiological agonism and antagonism

Physiological agonism and antagonism

Physiological agonism and antagonism is the mechanism of substances to induce the same ultimate effects in the body as other substances, as if they were receptor agonists or antagonists, but without binding to the same receptor.

Examples

Physiological agonists

*Adrenaline induces platelet aggregation and so does hepatocyte growth factor (HGF) [ [http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6T36-4GNKKH4-7&_user=10&_coverDate=08%2F15%2F2005&_rdoc=1&_fmt=&_orig=search&_sort=d&view=c&_acct=C000050221&_version=1&_urlVersion=0&_userid=10&md5=d2a9455c84d230d0bd247b2b0c7eb169 doi:10.1016/j.febslet.2005.06.072 Met identification on human platelets: Role of hepatocyte growth factor in the modulation of platelet activation] Copyright © 2005 Published by Elsevier B.V. Edited by Veli-Pekka Lehto. Daniela Pietrapiana, Marilena Sala, Maria Prat1 and Fabiola Sinigaglia, 1, Department of Medical Science, University “A. Avogadro”, Via Solaroli, 17, Novara 28100, Italy Received 4 May 2005; revised 15 June 2005; accepted 21 June 2005. Available online 19 July 2005. ] . Thus, they are physiological agonists to each other.

Physiological antagonists

*There are several "physiological antagonists" that have antihistaminergic action. For instance, adrenaline raises arterial pressure through vasoconstriction mediated by β-adrenergic receptor activation, in contrast to the histamine effect of lowering arterial pressure. However, only such substances that bind and block the histamine receptor are true antihistamines.

References


Wikimedia Foundation. 2010.

Игры ⚽ Поможем сделать НИР

Look at other dictionaries:

  • Drug tolerance — Physiological tolerance or drug tolerance is commonly encountered in pharmacology, when a subject s reaction to a drug (such as an opiate painkiller, benzodiazepine or other psychotropic drug) is reduced at a later time even though the dose or… …   Wikipedia

  • Receptor antagonist — This article is about the biochemistry term. For other uses, see Antagonist (disambiguation). Antagonists will block the binding of an agonist at a receptor molecule, inhibiting the signal produced by a receptor agonist coupling. A receptor… …   Wikipedia

  • Pharmacodynamics — Pharmacokinetics may be simply defined as what the body does to the drug, as opposed to pharmacodynamics which may be defined as what the drug does to the body.[1] “ …   Wikipedia

  • Agonist — For other meanings of agonist or agonism , see agonist (disambiguation). For a primary fictional character in a work, see Protagonist and Antagonist. Agonists …   Wikipedia

  • Beta blocker — Beta blockers Drug class Skeletal formula of propranolol, the first clinically successful beta blocker ATC code C07 …   Wikipedia

  • Neuropsychopharmacology — For the journal, see Neuropsychopharmacology (journal). Neuropsychopharmacology (from Greek νεῦρον, neuron, nerve ; ψυχή, psyche, mind , soul ; φάρμακον, pharmakon, poison in classic Greek; drug in modern Greek and the suffix λογία, logia, study… …   Wikipedia

  • Bioavailability — In pharmacology, bioavailability (BA) is a subcategory of absorption and is used to describe the fraction of an administered dose of unchanged drug that reaches the systemic circulation, one of the principal pharmacokinetic properties of drugs.… …   Wikipedia

  • Drug metabolism — is the biochemical modification of pharmaceutical substances by living organisms, usually through specialized enzymatic systems. This is a form of xenobiotic metabolism. Drug metabolism often converts lipophilic chemical compounds into more… …   Wikipedia

  • Median lethal dose — This article is about the toxicological term. For the album by Mudvayne, see L.D. 50 (album). For other uses, see LD50 (disambiguation). In toxicology, the median lethal dose, LD50 (abbreviation for “Lethal Dose, 50%”), LC50 (Lethal Concentration …   Wikipedia

  • Dose-response relationship — Semi log plots of two agonists with different Kd. The dose response relationship, or exposure response relationship, describes the change in effect on an organism caused by differing levels of exposure (or doses) to a stressor (usually a… …   Wikipedia

Share the article and excerpts

Direct link
Do a right-click on the link above
and select “Copy Link”