TonB-dependent receptors

TonB-dependent receptors

Pfam_box
Symbol = TonB_dep_Rec
Name = TonB dependent receptor



width =250
caption =
Pfam= PF00593
InterPro= IPR000531
SMART=
PROSITE = PDOC00354
SCOP = 2fcp
TCDB = 1.B.14
OPM family= 89
OPM protein= 1qfg
PDB=PDB3|1fepA:465-746 PDB3|1nqfA:390-614 PDB3|1ujwA:390-614PDB3|1nqhA:390-614 PDB3|1nqeA:390-614 PDB3|1nqgA:390-614PDB3|1qfgA:510-747 PDB3|1by5A:510-747 PDB3|1qkcA:510-747PDB3|1by3A:510-747 PDB3|2fcpA:510-747 PDB3|1fcpA:510-747PDB3|1qjqA:510-747 PDB3|1qffA:510-747 PDB3|1fi1A:510-747PDB3|1xkhA:570-815 PDB3|1xkwA:478-720 PDB3|1kmoA:525-774PDB3|1kmpA:525-774 PDB3|1po3B:525-774 PDB3|1pnzA:525-774PDB3|1po0A:525-774

TonB-dependent receptors is a family of beta-barrel proteins from the outer membrane of Gram-negative bacteria. The TonB complex senses signals from outside the bacterial cell and transmits them via two membranes into the cytoplasm, leading to transcriptional activation of target genes.

In "Escherichia coli" the TonB protein interacts with outer membrane receptor proteins that carry out high-affinity binding and energy-dependent uptake of specific substrates into the periplasmic spacecite journal |author=Kadner RJ, Chimento DP, Wiener MC |title=The Escherichia coli outer membrane cobalamin transporter BtuB: structural analysis of calcium and substrate binding, and identification of orthologous transporters by sequence/structure conservation |journal=J. Mol. Biol. |volume=332 |issue=5 |pages=999–1014 |year=2003 |pmid=14499604 |doi=10.1016/j.jmb.2003.07.005] . These substrates are either poorly permeable through the porin channels or are encountered at very low concentrations. In the absence of TonB, these receptors bind their substrates but do not carry out active transport. TonB-dependent regulatory systems consist of six protein protein components cite journal |author=Koebnik R |title=TonB-dependent trans-envelope signalling: the exception or the rule? |journal=Trends Microbiol. |volume=13 |issue=8 |pages=- |year=2005 |pmid=15993072 |doi=10.1016/j.tim.2005.06.005] .

The proteins that are currently known or presumed to interact with TonB include BtuBcite journal |author=Kadner RJ, Chimento DP, Wiener MC, Mohanty AK |title=Substrate-induced transmembrane signaling in the cobalamin transporter BtuB |journal=Nat. Struct. Biol. |volume=10 |issue=5 |pages=394–401 |year=2003 |pmid=12652322 |doi=10.1038/nsb914] , CirA, FatA, FcuT, FecAcite journal |author=Deisenhofer J, Smith BS, Esser L, Chakraborty R, van der Helm D, Ferguson AD |title=Structural basis of gating by the outer membrane transporter FecA |journal=Science |volume=295 |issue=5560 |pages=1715–1719 |year=2002 |pmid=11872840 |doi=10.1126/science.1067313] , FhuAcite journal |author=Moras D, Rosenbusch JP, Mitschler A, Rees B, Locher KP, Koebnik R, Moulinier L |title=Transmembrane signaling across the ligand-gated FhuA receptor: crystal structures of free and ferrichrome-bound states reveal allosteric changes |journal=Cell |volume=95 |issue=6 |pages=771–778 |year=1998 |pmid=9865695 |doi=10.1016/S0092-8674(00)81700-6] , FhuE, FepAcite journal |author=Deisenhofer J, Xia D, Buchanan SK, Smith BS, Venkatramani L, Esser L, Palnitkar M, Chakraborty R, van der Helm D |title=Crystal structure of the outer membrane active transporter FepA from Escherichia coli |journal=Nat. Struct. Biol. |volume=6 |issue=1 |pages=56–63 |year=1999 |pmid=9886293 |doi=10.1038/4931] , FptA, HemR, IrgA, IutA, PfeA, PupA and Tbp1. The TonB protein also interacts with some colicins. Most of these proteins contain a short conserved region at their N-terminuscite journal |author=Klebba PE |title=Three paradoxes of ferric enterobactin uptake |journal=Front. Biosci. |volume=8 |issue= |pages=- |year=2003 |pmid=12957833 |doi=10.2741/1233] .

TonB-dependent receptors include a plug domain which acts as the channel gate, blocking the pore until the channel is bound by ligand. At this point it under goes conformational changes opens the channel.

References


Wikimedia Foundation. 2010.

Игры ⚽ Поможем сделать НИР

Look at other dictionaries:

  • TonB-dependent receptor plug domain — Pfam box Symbol = Plug Name = TonB dependent Receptor Plug Domain width =250 caption = Pfam= PF07715 InterPro= IPR012910 SMART= Prosite = SCOP = 1fi1 TCDB = OPM family= 33 OPM protein= 1qfg PDB=PDB3|1qfgA:75 181 PDB3|1by5A:75 181 PDB3|1qkcA:75… …   Wikipedia

  • CrfA RNA — Conserved secondary structure of CrfA RNA. Identifiers Symbol CrfA Other data Domain(s) Caulobacter …   Wikipedia

  • Transmembrane protein — A transmembrane protein is a protein that spans the entire biological membrane. Transmembrane proteins aggregate and precipitate in water. They require detergents or nonpolar solvents for extraction, although some of them (beta barrels) can be… …   Wikipedia

Share the article and excerpts

Direct link
Do a right-click on the link above
and select “Copy Link”