Matrix metalloproteinase inhibitor

Matrix metalloproteinase inhibitor

A matrix metalloproteinase inhibitor (MMPI) inhibits matrix metalloproteinases. As they inhibit cell migration they have antiangiogenic effects. They may be both endogenous and exogenous.

The most notorious endogenous metalloproteinases are tissue inhibitor of metalloproteinases (TIMP). There are also cartilage-derived angiogenesis inhibitor‎s.

Exogenous matrix metalloproteinase inhibitors include batimastat and marimastat.



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